Role of myostatin protein in sarcopenia (aging muscle) after conditioned medium umbilical cord mesenchymal stem cells (secretome) therapy: mini review

Umbilical Cord Mesenchyme stem cell (UC-MSCs) /secretome has been applied for treating several diseases, such as cardio-protection and diabetes. Secretome-derived paracrine modulating effects of various growth factors, cytokines, chemokines, angiogenic exosomes are used in aging therapy. In recent clinical trials on sarcopenia therapy pharmaceutical interventions, nutrition, physical exercise reported to be effective strategies reduce sarcopenia. The pathomechanism the secretome treatment is unclear. This study looked into how might affect myostatin, a biomarker sarcopenia, at molecular level. Myostatin, member TGF-family, significantly increases muscle when it absent while suppressing present. A bioactive substance called secreted by MSCs conditioned conditions. It rich factors which crucial speeding up tissue regeneration. Secretome intervention promising approach showed its ability prevent loss improve biomarkers.